Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.

Nucleic acids research - 1 Jan 2015

Schultz Bryant M, Gallicio Gwendolyn A, Cesaroni Matteo, Lupey Lena N, Engel Nora

Abstract excerpt

The imprinted Kcnq1 domain contains a differentially methylated region (KvDMR) in intron 11 of Kcnq1. The Kcnq1ot1 non-coding RNA emerges from the unmethylated paternal KvDMR in antisense direction, resulting in cis-repression of neighboring genes. The KvDMR encompasses the Kcnq1ot1 promoter, CTCF sites and other DNA elements, whose individual contribution to regulation of the endogenous domain is unknown. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCCTC-Binding Factor
Share to Cyclin-Dependent Kinase Inhibitor p57

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Genomic Imprinting

Share to KCNQ1 Potassium Channel

Share to Myocardium

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 25539921
DOI: 10.1093/nar/gku1324
PMCID: PMC4333379

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhancers compete with a long non-coding RNA for regulation of the Kcnq1 domain.PMID 25539921Read ↗

The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.Semantic proximity Read ↗

Allele-specific binding of CTCF to the multipartite imprinting control region KvDMR1.Semantic proximity Read ↗

A differentially methylated region within the gene Kcnq1 functions as an imprinted promoter and silencerSemantic proximity Read ↗

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.Semantic proximity Read ↗

Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by interacting with Dnmt1.Semantic proximity Read ↗

Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo.Semantic proximity Read ↗

Antisense noncoding RNA promoter regulates the timing of de novo methylation of an imprinting control region.Semantic proximity Read ↗

Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndromeSemantic proximity Read ↗

An antisense RNA regulates the bidirectional silencing property of the Kcnq1 imprinting control region.Semantic proximity Read ↗

A differentially methylated imprinting control region within the Kcnq1 locus harbors a methylation-sensitive chromatin insulator.Semantic proximity Read ↗

Strain-dependent developmental relaxation of imprinting of an endogenous mouse gene, Kvlqt1.Semantic proximity Read ↗

The KCNQ1OT1 promoter, a key regulator of genomic imprinting in human chromosome 11p15.5.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.