Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.

doi:10.1073/pnas.1422104112

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Article

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2015

Asahara Shun-ichiro, Etoh Hiroaki, Inoue Hiroyuki, Teruyama Kyoko, Shibutani Yuki, Ihara Yuka, Kawada Yukina, Bartolome Alberto, Hashimoto Naoko, Matsuda Tomokazu, Koyanagi-Kimura Maki, Kanno Ayumi, Hirota Yushi, Hosooka Tetsuya, Nagashima Kazuaki, Nishimura Wataru, Inoue Hiroshi, Matsumoto Michihiro, Higgins Michael J, Yasuda Kazuki, Inagaki Nobuya, Seino Susumu, Kasuga Masato, Kido Yoshiaki

Abstract excerpt

Genetic factors are important determinants of the onset and progression of diabetes mellitus. Numerous susceptibility genes for type 2 diabetes, including potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1), have been identified in humans by genome-wide analyses and other studies. Experiments with genetically modified mice have also implicated various genes in the pathogenesis of diabetes....

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Identifiers

PMID: 26100882
DOI: 10.1073/pnas.1422104112
PMCID: PMC4500236

Genes

KCNQ1

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Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.PMID 26100882Read ↗

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