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Article

Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.

PLoS genetics - 1 Sept 2012

Riddle Nicole C, Jung Youngsook L, Gu Tingting, Alekseyenko Artyom A, Asker Dalal, Gui Hongxing, Kharchenko Peter V, Minoda Aki, Plachetka Annette, Schwartz Yuri B, Tolstorukov Michael Y, Kuroda Mitzi I, Pirrotta Vincenzo, Karpen Gary H, Park Peter J, Elgin Sarah C R

Abstract excerpt

Chromatin environments differ greatly within a eukaryotic genome, depending on expression state, chromosomal location, and nuclear position. In genomic regions characterized by high repeat content and high gene density, chromatin structure must silence transposable elements but permit expression of embedded genes. We have investigated one such region, chromosome 4 of Drosophila melanogaster. Using...

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Identifiers

PMID: 23028361
DOI: 10.1371/journal.pgen.1002954
PMCID: PMC3447959

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Source receipt: pubmed, retrieved 7 Sept 2026.

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