Article
A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster.
Genetics - 1 Apr 2005
Schulze Sandra R, Sinclair Donald A R, Fitzpatrick Kathleen A, Honda Barry M
Abstract excerpt
Heterochromatin comprises a transcriptionally repressive chromosome compartment in the eukaryotic nucleus; this is exemplified by the silencing effect it has on euchromatic genes that have been relocated nearby, a phenomenon known as position-effect variegation (PEV), first demonstrated in Drosophila melanogaster. However, the expression of essential heterochromatic genes within these apparently repressive...
Topics
- Alleles
- Animals
- Base Sequence
- Binding Sites
- Blotting, Northern
- Blotting, Southern
- Cell Survival
- Chromatin
- Chromosome Mapping
- Cloning, Molecular
- Crosses, Genetic
- DNA, Complementary
- Drosophila Proteins
- Drosophila melanogaster