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Article

A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster.

Genetics - 1 Apr 2005

Schulze Sandra R, Sinclair Donald A R, Fitzpatrick Kathleen A, Honda Barry M

Abstract excerpt

Heterochromatin comprises a transcriptionally repressive chromosome compartment in the eukaryotic nucleus; this is exemplified by the silencing effect it has on euchromatic genes that have been relocated nearby, a phenomenon known as position-effect variegation (PEV), first demonstrated in Drosophila melanogaster. However, the expression of essential heterochromatic genes within these apparently repressive...

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Identifiers

PMID: 15687284
DOI: 10.1534/genetics.103.023341
PMCID: PMC1449577

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