Article
The SU(VAR)3-9/HP1 complex differentially regulates the compaction state and degree of underreplication of X chromosome pericentric heterochromatin in Drosophila melanogaster.
Genetics - 1 Feb 2007
Demakova Olga V, Pokholkova Galina V, Kolesnikova Tatyana D, Demakov Sergey A, Andreyeva Eugenia N, Belyaeva Elena S, Zhimulev Igor F
Abstract excerpt
In polytene chromosomes of Drosophila melanogaster, regions of pericentric heterochromatin coalesce to form a compact chromocenter and are highly underreplicated. Focusing on study of X chromosome heterochromatin, we demonstrate that loss of either SU(VAR)3-9 histone methyltransferase activity or HP1 protein differentially affects the compaction of different pericentric regions. Using a set of inversions breaking...
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