Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between the -174 C/G polymorphism in the interleukin-6 (IL-6) gene and gastrointestinal involvement in patients with systemic sclerosis.

Clinical rheumatology - 1 Sept 2018

Zekovic Ana, Vreca Misa, Spasovski Vesna, Andjelkovic Marina, Pavlovic Sonja, Damjanov Nemanja

Abstract excerpt

Genetic predisposition to systemic sclerosis (SSc) has still not been fully revealed. Interleukin-6 (IL-6) is a mediator of T cell proliferation and fibrotic events in SSc. Polymorphisms in the IL-6 are found to be important in susceptibility to development of SSc. We aimed to assess the frequency of -174 C/G of IL-6 gene polymorphism in SSc patients and healthy controls, as well as correlation with disease...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Gastrointestinal Diseases

Share to Gene Frequency

Share to Interleukin-6

Share to Scleroderma, Systemic

Share to Serbia

Source

Identifiers

PMID: 29948346
DOI: 10.1007/s10067-018-4163-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between the -174 C/G polymorphism in the interleukin-6 (IL-6) gene and gastrointestinal involvement in patients with systemic sclerosis.PMID 29948346Read ↗

The IL-6 promoter polymorphism is associated with disease activity and disability in systemic sclerosis.Semantic proximity Read ↗

Influence of the IL6 gene in susceptibility to systemic sclerosis.Semantic proximity Read ↗

No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis.Semantic proximity Read ↗

Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis.Semantic proximity Read ↗

Interleukin-6: it’s role in the organism, genetic polymorphism and significance in certain diseases (literature review)Semantic proximity Read ↗

Association of IL -6 -174 G>C polymorphism with the risk of SLE among south Indians: evidence from case-control study and meta-analysis.Semantic proximity Read ↗

Multiple genes, especially immune-regulating genes, contribute to disease susceptibility in systemic sclerosis.Semantic proximity Read ↗

The status of pulmonary fibrosis in systemic sclerosis is associated with IRF5, STAT4, IRAK1, and CTGF polymorphisms.Semantic proximity Read ↗

Peripheral blood IL-6 levels in systemic sclerosis patients: Correlation between IL-6 levels and clinical phenotypes.Semantic proximity Read ↗

Role of the promoter polymorphism IL-6 -174G/C in dermatomyositis and systemic lupus erythematosus.Semantic proximity Read ↗

Interleukin-6 gene polymorphism in Iranian patients with systemic lupus erythematosus.Semantic proximity Read ↗

Interleukin-6 promoter polymorphism (-174 G/C) in Caucasian German patients with systemic lupus erythematosusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.