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Article

No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and systemic sclerosis.

Tissue antigens - 1 Sept 2012

Cénit M C, Simeón C P, Fonollosa V, Espinosa G, Beltrán E, Sáez-Comet L, Vicente-Rabaneda E, García-Hernández F J, Martínez-Estupiñán L, Rodríguez-Carballeira M, Hernández V, de la Peña P G, Fernández-Castro M, Narváez F J, Pros A, Gallego M, Ríos-Fernández R, Camps M T, Fernández-Nebro A, Egurbide M V, Carreira P, González-Gay M A, Martín J

Abstract excerpt

Systemic sclerosis (SSc) is a complex autoimmune disease which genetic component has not been yet completely understood. IL6 encodes a cytokine with a crucial role in the development of autoimmunity and fibrosis and its actions mainly are controlled by IL-6 receptor (IL-6R). We aimed to investigate whether the functional genetic variants rs8192284 and rs2228044 previously associated with several autoimmune...

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Share to Case-Control Studies
Share to Cytokine Receptor gp130
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Share to Scleroderma, Systemic

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Identifiers

PMID: 22742541
DOI: 10.1111/j.1399-0039.2012.01915.x

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