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Article

Two clinical isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B both harbor mutations in ERG2.

Antimicrobial agents and chemotherapy - 1 Dec 2012

Hull Claire M, Bader Oliver, Parker Josie E, Weig Michael, Gross Uwe, Warrilow Andrew G S, Kelly Diane E, Kelly Steven L

Abstract excerpt

Two novel isolates of Candida glabrata exhibiting reduced sensitivity to amphotericin B (MIC, 8 μg ml(-1)) were found to be ERG2 mutants, wherein Δ(8)-sterol intermediates comprised >90% of the total cellular sterol fraction. Both harbored an alteration at Thr(121) in ERG2; the corresponding resi...

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Identifiers

PMID: 23027188
DOI: 10.1128/AAC.01145-12
PMCID: PMC3497184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23027188-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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