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Article

Mathematical model of colitis-associated colon cancer.

Journal of theoretical biology - 21 Jan 2013

Lo Wing-Cheong, Martin Edward W, Hitchcock Charles L, Friedman Avner

Abstract excerpt

As a result of chronic inflammation of their colon, patients with ulcerative colitis or Crohn's disease are at risk of developing colon cancer. In this paper, we consider the progression of colitis-associated colon cancer. Unlike normal colon mucosa, the inflammed colon mucosa undergoes genetic mutations, affecting, in particular, tumor suppressors TP53 and adenomatous polyposis coli (APC) gene. We develop a...

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Identifiers

PMID: 23026764
DOI: 10.1016/j.jtbi.2012.09.025

Genes

APC
MUC1
MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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