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Article

Linear Model of Colon Cancer Initiation

1 Mar 2004

Abstract excerpt

Cancer results if regulatory mechanisms of cell birth and death are disrupted. Colorectal tumorigenesis is initiated by somatic or inherited mutations in the APC tumor suppressor gene pathway. Several additional genetic hits in other tumor suppressor genes and oncogenes drive the progression from polyps to malignant, invasive cancer. The majority of colorectal cancers present chromosomal instability, CIN, which...

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Identifiers

PMID: 14726709
DOI: 10.4161/cc.3.3.690

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