Article
Multistage carcinogenesis: population-based model for colon cancer.
Journal of the National Cancer Institute - 15 Apr 1992
Moolgavkar S H, Luebeck E G
Abstract excerpt
BACKGROUND: Recent laboratory work and previous models suggest that multiple mutations are associated with the development of colon cancer. PURPOSE AND METHODS: To estimate the number of mutations required for colon carcinogenesis, we used likelihood analysis to obtain the best fit between mathem...
Topics
- Adenomatous Polyposis Coli
- Colonic Neoplasms
- England
- Humans
- Incidence
- Models, Genetic
- Mutation