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Article

Multistage carcinogenesis: population-based model for colon cancer.

Journal of the National Cancer Institute - 15 Apr 1992

Moolgavkar S H, Luebeck E G

Abstract excerpt

BACKGROUND: Recent laboratory work and previous models suggest that multiple mutations are associated with the development of colon cancer. PURPOSE AND METHODS: To estimate the number of mutations required for colon carcinogenesis, we used likelihood analysis to obtain the best fit between mathematical models postulating different numbers of rate-limiting events and data on incidence rates of colon cancer in two...

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PMID: 1313509
DOI: 10.1093/jnci/84.8.610

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FAP

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