Article
Kinin B1 receptor in adipocytes regulates glucose tolerance and predisposition to obesity.
PloS one - 1 Jan 2012
Mori Marcelo A, Sales Vicência Micheline, Motta Fabiana Louise, Fonseca Raphael Gomes, Alenina Natalia, Guadagnini Dioze, Schadock Ines, Silva Elton Dias, Torres Hugo A M, dos Santos Edson Lucas, Castro Charlles Heldan, D'Almeida Vânia, Andreotti Sandra, Campaña Amanda Baron, Sertié Rogério A L, Saad Mario J A, Lima Fabio Bessa, Bader Michael, Pesquero João Bosco
Abstract excerpt
BACKGROUND: Kinins participate in the pathophysiology of obesity and type 2 diabetes by mechanisms which are not fully understood. Kinin B(1) receptor knockout mice (B(1) (-/-)) are leaner and exhibit improved insulin sensitivity. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that kinin B(1) receptors in adipocytes play a role in controlling whole body insulin action and glucose homeostasis. Adipocytes isolated...
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