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Article

The bradykinin system in stress and anxiety in humans and mice.

Scientific reports - 19 Dec 2019

Rouhiainen Ari, Kulesskaya Natalia, Mennesson Marie, Misiewicz Zuzanna, Sipilä Tessa, Sokolowska Ewa, Trontti Kalevi, Urpa Lea, McEntegart William, Saarnio Suvi, Hyytiä Petri, Hovatta Iiris

Abstract excerpt

Pharmacological research in mice and human genetic analyses suggest that the kallikrein-kinin system (KKS) may regulate anxiety. We examined the role of the KKS in anxiety and stress in both species. In human genetic association analysis, variants in genes for the bradykinin precursor (KNG1) and the bradykinin receptors (BDKRB1 and BDKRB2) were associated with anxiety disorders (p < 0.05). In mice, however,...

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Identifiers

PMID: 31857655
DOI: 10.1038/s41598-019-55947-5
PMCID: PMC6923437

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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