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Article

Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.

Molecular and cellular biology - 1 Nov 2010

Lennerz Jochen K, Hurov Jonathan B, White Lynn S, Lewandowski Katherine T, Prior Julie L, Planer G James, Gereau Robert W, Piwnica-Worms David, Schmidt Robert E, Piwnica-Worms Helen

Abstract excerpt

Par-1 is an evolutionarily conserved protein kinase required for polarity in worms, flies, frogs, and mammals. The mammalian Par-1 family consists of four members. Knockout studies of mice implicate Par-1b/MARK2/EMK in regulating fertility, immune homeostasis, learning, and memory as well as adip...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20733003
DOI: 10.1128/MCB.01472-09
PMCID: PMC2953066

Genes

MARK3
MARK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20733003-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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