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Article

Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency.

Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2017

Lorenzo Damaris N, Bennett Vann

Abstract excerpt

Obesity typically is linked to caloric imbalance as a result of overnutrition. Here we propose a cell-autonomous mechanism for adiposity as a result of persistent cell surface glucose transporter type 4 (GLUT4) in adipocytes resulting from impaired function of ankyrin-B (AnkB) in coupling GLUT4 to clathrin-mediated endocytosis. Adipose tissue-specific AnkB-KO mice develop obesity and progressive pancreatic islet...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29133412
DOI: 10.1073/pnas.1708865114
PMCID: PMC5715754

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