Anti-CD3 monoclonal antibody-mediated cytotoxicity occurs through an interleukin-2-independent pathway in CD3+ large granular lymphocytes.

Article

Anti-CD3 monoclonal antibody-mediated cytotoxicity occurs through an interleukin-2-independent pathway in CD3+ large granular lymphocytes.

Blood - 15 Feb 1990

Loughran T P, Aprile J A, Ruscetti F W

Abstract excerpt

The mechanism of induction of cytotoxicity produced by anti-CD3 monoclonal antibody (MoAb) was studied in four patients with CD3+ large granular lymphocyte (LGL) leukemia. Anti-CD3 MoAb treatment resulted in increased target cell binding and increased granule formation. After activation, leukemic...

Topics

Antibodies, Monoclonal
Antibody-Dependent Cell Cytotoxicity
Antigens, CD
Blotting, Northern
Humans
Interleukin-2
Killer Cells, Natural
Microscopy, Electron
Phenotype

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