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Article

Cell membrane expression and functional role of the p75 subunit of interleukin-2 receptor in lymphoproliferative disease of granular lymphocytes.

Blood - 15 Nov 1990

Zambello R, Trentin L, Pizzolo G, Bulian P, Masciarelli M, Feruglio C, Agostini C, Raimondi R, Chisesi T, Semenzato G

Abstract excerpt

The cell membrane expression and functional role of the interleukin-2 receptor (IL-2R) was analyzed in nine patients with lymphoproliferative disease of granular lymphocytes (LDGL) using monoclonal antibodies (MoAbs) specific for the p75 (TU27) and the p55 (anti-Tac) subunits of IL-2R. Four patients were characterized by the proliferation of CD3+CD8+ granular lymphocytes (GL) expressing the alpha/beta T-cell...

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PMID: 2146981

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