Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell membrane expression and functional role of the p75 subunit of interleukin-2 receptor in lymphoproliferative disease of granular lymphocytes.

Blood - 15 Nov 1990

Zambello R, Trentin L, Pizzolo G, Bulian P, Masciarelli M, Feruglio C, Agostini C, Raimondi R, Chisesi T, Semenzato G

Abstract excerpt

The cell membrane expression and functional role of the interleukin-2 receptor (IL-2R) was analyzed in nine patients with lymphoproliferative disease of granular lymphocytes (LDGL) using monoclonal antibodies (MoAbs) specific for the p75 (TU27) and the p55 (anti-Tac) subunits of IL-2R. Four patients were characterized by the proliferation of CD3+CD8+ granular lymphocytes (GL) expressing the alpha/beta T-cell...

Topics

Adult
Aged
Antibodies, Monoclonal
Antigens, Differentiation, T-Lymphocyte
CD3 Complex
Cell Division
Cell Membrane
Cytotoxicity, Immunologic
Female
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Lymphocyte Activation

Lymphocytes

Lymphoproliferative Disorders

Male

Middle Aged

Phenotype

Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 2146981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2146981-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell membrane expression and functional role of the p75 subunit of interleukin-2 receptor in lymphoproliferative disease of granular lymphocytes.PMID 2146981Read ↗

Different mechanisms of activation of proliferating CD3+ cells in patients with lymphoproliferative disease of granular lymphocytes.Semantic proximity Read ↗

Activation of leukemic large granular lymphocytes by interleukin-2 via the p75 interleukin-2 receptor.Semantic proximity Read ↗

Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes.Semantic proximity Read ↗

Clonally expanded CD3+, CD4-, CD8- cells bearing the alpha/beta or the gamma/delta T-cell receptor in patients with the lymphoproliferative disease of granular lymphocytes.Semantic proximity Read ↗

Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes.Semantic proximity Read ↗

Natural killer cells activated by interleukin 2 treatment in vivo respond to interleukin 2 primarily through the p75 receptor and maintain the p55 (TAC) negative phenotype.Semantic proximity Read ↗

Immunological and genotypic analysis of human T gamma-lymphoproliferative disorders.Semantic proximity Read ↗

Anti-CD3 monoclonal antibody-mediated cytotoxicity occurs through an interleukin-2-independent pathway in CD3+ large granular lymphocytes.Semantic proximity Read ↗

Restricted expression of p55 interleukin 2 receptor (CD25) on normal T cells.Semantic proximity Read ↗

Proliferative responses to PHA, anti-CD3 and antigens in patients with lymphoproliferative disease of granular lymphocytes. Mannoproteins of Candida albicans induce proliferation and cytotoxicity.Semantic proximity Read ↗

Differential expression of interleukin‐2 receptors (α and β chain) in mature lymphoid neoplasmsSemantic proximity Read ↗

Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.