Article
Preclinical studies for adoptive immunotherapy in bone marrow transplantation. Generation of anti-CD3 activated cytotoxic T cells from normal donors and autologous bone marrow transplant candidates.
Transplantation - 1 Aug 1993
Ueda M, Joshi I D, Dan M, Uberti J P, Chou T H, Sensenbrenner L L, Lum L G
Abstract excerpt
In order to obtain T cells for adoptive immunotherapy after autologous bone marrow transplantation (ABMT) for patients with resistant hematological malignancies, a culture system was developed for growing T cells and inducing non-MHC-restricted cytotoxicity using anti-CD3 monoclonal antibody (OKT...
Topics
- Antibodies
- Bone Marrow
- Bone Marrow Cells
- Bone Marrow Transplantation
- CD3 Complex
- Cell Division
- Combined Modality Therapy
- Cryopreservation
- Humans
- Immunotherapy, Adoptive
- Interleukin-2
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Acute