Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia.

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Article

Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia.

Blood - 15 Dec 1998

Lamy T, Liu J H, Landowski T H, Dalton W S, Loughran T P

Abstract excerpt

CD95 (Fas)-induced apoptosis plays a critical role in the elimination of activated lymphocytes and induction of peripheral tolerance. Defects in CD95/CD95L (Fas-Ligand)-apoptotic pathway have been recognized in autoimmune lymphoproliferative diseases (ALPS) and lpr or gld mice and attributed to C...

Topics

Adult
Aged
Antibodies, Monoclonal
Apoptosis
CD3 Complex
Cells, Cultured
Fas Ligand Protein
Female
Flow Cytometry
Gene Expression Regulation, Neoplastic
Humans
Leukemia, Lymphoid
Leukocytes, Mononuclear
Male
Membrane Glycoproteins
Middle Aged
Mutation
Polymorphism, Single-Stranded Conformational

Source

Open in PubMed

Identifiers

PMID: 9845544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9845544-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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