Article
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.
The Journal of experimental medicine - 1 Aug 1992
Baixeras E, Huard B, Miossec C, Jitsukawa S, Martin M, Hercend T, Auffray C, Triebel F, Piatier-Tonneau D
Abstract excerpt
The lymphocyte activation gene 3 (LAG-3), expressed in human activated T and natural killer (NK) cells, is closely related to CD4 at the gene and protein levels. We report here the initial characterization of the LAG-3-encoded protein. We have generated two monoclonal antibodies after immunization of mice with a 30-amino acid peptide that corresponds to an exposed extra loop region present in the LAG-3...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antigens, CD
- B-Lymphocytes
- Cell Adhesion
- Cell Line
- Cells, Cultured
- Cloning, Molecular
- Epitopes
- Histocompatibility Antigens Class II