Article
Molecular analysis of T cell receptor and CD3 genes in CD3- large granular lymphocytes (LGLs): evidence for the existence of CD3- LGLs committed to the T cell lineage.
Leukemia - 1 Aug 1990
Hara J, Yumura-Yagi K, Tagawa S, Ishihara S, Tawa A, Ninomiya T, Wakiguchi H, Shimazaki C, Kitani T, Kawa-Ha K
Abstract excerpt
Seven patients with CD3- lymphoproliferative disorder of granular lymphocytes (LDGL) were analyzed for rearrangement of the T cell receptor (TCR) delta and alpha as well as gamma and beta genes. Among those patients six showed the germline configuration of all known rearranging TCR genes. Two analyzed patients of them lacked CD3-gamma transcripts and expressed nonfunctional TCR-beta transcripts. Meanwhile,...
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