Article
Molecular analysis of T cell receptor and CD3 genes in CD3- large granular lymphocytes (LGLs): evidence for the existence of CD3- LGLs committed to the T cell lineage.
Leukemia - 1 Aug 1990
Hara J, Yumura-Yagi K, Tagawa S, Ishihara S, Tawa A, Ninomiya T, Wakiguchi H, Shimazaki C, Kitani T, Kawa-Ha K
Abstract excerpt
Seven patients with CD3- lymphoproliferative disorder of granular lymphocytes (LDGL) were analyzed for rearrangement of the T cell receptor (TCR) delta and alpha as well as gamma and beta genes. Among those patients six showed the germline configuration of all known rearranging TCR genes. Two ana...
Topics
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- Cytoplasmic Granules
- Gene Rearrangement, T-Lymphocyte
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
- Humans
- Lymphoproliferative Disorders
- Phenotype
- Receptors, Antigen, T-Cell
- Restriction Mapping
- T-Lymphocytes