Article
Anti-GD3 monoclonal antibody analysis of childhood T-cell acute lymphoblastic leukemia: detection of a target antigen for antibody-mediated cytolysis.
Cancer research - 1 Jan 1990
Reaman G H, Taylor B J, Merritt W D
Abstract excerpt
We have demonstrated in previous studies significant quantitative differences in the ganglioside content of leukemia cell membranes within immunological subclasses of acute lymphoblastic leukemia (ALL): The disialoganglioside GD3 (disialolactosylceramide) is increased in lymphoblasts with a T-cel...
Topics
- Antibodies, Monoclonal
- Antibody-Dependent Cell Cytotoxicity
- Antigens, CD
- Antigens, Neoplasm
- Child
- Complement System Proteins
- Cytotoxicity, Immunologic
- Fluorescent Antibody Technique
- Gangliosides
- Humans
- Leukemia-Lymphoma, Adult T-Cell
- Phenotype
- Tumor Cells, Cultured