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Article

Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.

Genetics - 1 Dec 2012

Gürel Güliz, Gustafson Megan A, Pepper Judy S, Horvitz H Robert, Koelle Michael R

Abstract excerpt

A better understanding of the molecular mechanisms of signaling by the neurotransmitter serotonin is required to assess the hypothesis that defects in serotonin signaling underlie depression in humans. Caenorhabditis elegans uses serotonin as a neurotransmitter to regulate locomotion, providing a genetic system to analyze serotonin signaling. From large-scale genetic screens we identified 36 mutants of C. elegans...

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Identifiers

PMID: 23023001
DOI: 10.1534/genetics.112.142125
PMCID: PMC3512144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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