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Article

Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans.

Nature neuroscience - 1 Oct 2004

Chase Daniel L, Pepper Judy S, Koelle Michael R

Abstract excerpt

D1-like and D2-like dopamine receptors have synergistic and antagonistic effects on behavior. To understand the mechanisms underlying these effects, we studied dopamine signaling genetically in Caenorhabditis elegans. Knocking out a D2-like receptor, DOP-3, caused locomotion defects similar to those observed in animals lacking dopamine. Knocking out a D1-like receptor, DOP-1, reversed the defects of the DOP-3...

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PMID: 15378064
DOI: 10.1038/nn1316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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