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Article

A genetic survey of fluoxetine action on synaptic transmission in Caenorhabditis elegans.

Genetics - 1 Nov 2010

Kullyev Andrey, Dempsey Catherine M, Miller Sarah, Kuan Chih-Jen, Hapiak Vera M, Komuniecki Richard W, Griffin Christine T, Sze Ji Ying

Abstract excerpt

Fluoxetine is one of the most commonly prescribed medications for many behavioral and neurological disorders. Fluoxetine acts primarily as an inhibitor of the serotonin reuptake transporter (SERT) to block the removal of serotonin from the synaptic cleft, thereby enhancing serotonin signals. While the effects of fluoxetine on behavior are firmly established, debate is ongoing whether inhibition of serotonin...

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Identifiers

PMID: 20739712
DOI: 10.1534/genetics.110.118877
PMCID: PMC2975281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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