Article
Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo.
Neurochemistry international - 1 Sept 2016
Bermingham Daniel P, Hardaway J Andrew, Snarrenberg Chelsea L, Robinson Sarah B, Folkes Oakleigh M, Salimando Greg J, Jinnah Hussain, Blakely Randy D
Abstract excerpt
Modulation of neurotransmission by the catecholamine dopamine (DA) is conserved across phylogeny. In the nematode Caenorhabditis elegans, excess DA signaling triggers Swimming-Induced Paralysis (Swip), a phenotype first described in animals with loss of function mutations in the presynaptic DA transporter (dat-1). Swip has proven to be a phenotype suitable for the identification of novel dat-1 mutations as well...
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