Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.

Nature - 23 Nov 2000

Ranganathan R, Cannon S C, Horvitz H R

Abstract excerpt

The neurotransmitter and neuromodulator serotonin (5-HT) functions by binding either to metabotropic G-protein-coupled receptors (for example, 5-HT1, 5-HT2, 5-HT4 to 5-HT7), which mediate 'slow' modulatory responses through numerous second messenger pathways, or to the ionotropic 5-HT3 receptor, a non-selective cation channel that mediates 'fast' membrane depolarizations. Here we report that the gene mod-1 (for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Chloride Channels
Share to Genes, Helminth

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helminth Proteins

Share to Ion Channel Gating

Share to Patch-Clamp Techniques

Share to Serotonin

Share to Xenopus laevis

Source

Identifiers

PMID: 11100728
DOI: 10.1038/35044083

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.PMID 11100728Read ↗

Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.Semantic proximity Read ↗

The serotonin receptor SER-1 (5HT2ce) contributes to the regulation of locomotion in Caenorhabditis elegans.Semantic proximity Read ↗

Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.Semantic proximity Read ↗

Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine.Semantic proximity Read ↗

Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease.Semantic proximity Read ↗

Identification and characterization of a putative cyclic nucleotide-gated channel, CNG-1, in C. elegans.Semantic proximity Read ↗

Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit.Semantic proximity Read ↗

The cat-1 gene of Caenorhabditis elegans encodes a vesicular monoamine transporter required for specific monoamine-dependent behaviors.Semantic proximity Read ↗

Dopamine signaling in C. elegans is mediated in part by HLH-17-dependent regulation of extracellular dopamine levels.Semantic proximity Read ↗

Cocaine modulates locomotion behavior in C. elegans.Semantic proximity Read ↗

Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.