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Article

Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease.

Neurobiology of disease - 1 May 2021

Pereira-Sousa Joana, Ferreira-Lomba Bruna, Bellver-Sanchis Aina, Vilasboas-Campos Daniela, Fernandes Jorge H, Costa Marta D, Varney Mark A, Newman-Tancredi Adrian, Maciel Patrícia, Teixeira-Castro Andreia

Abstract excerpt

Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder that affects movement coordination leading to a premature death. Despite several efforts, no disease-modifying treatment is yet available for this disease. Previous studies pinpointed the modulation of serotonergic signaling, through pharmacological inhibition of the serotonin transporter SERT, as a...

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PMID: 33516872
DOI: 10.1016/j.nbd.2021.105278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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