Article
Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity.
Aging cell - 1 Aug 2007
Murakami Hana, Murakami Shin
Abstract excerpt
The neurotransmitter serotonin has been implicated in affecting the variation of longevity in natural Drosophila populations and age-related diseases in mammals. Based on these observations, it has been predicted that serotonin signal, perhaps at levels of serotonin biosynthesis, may control lifespan. Here, we investigated a variety of mutations in serotonin-signal genes, including serotonin biosynthesis genes, a...
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