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Article

Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel.

Journal of molecular biology - 10 Mar 2000

Imredy J P, MacKinnon R

Abstract excerpt

Dendrotoxin proteins isolated from Mamba snake venom block potassium channels with a high degree of specificity and selectivity. Using site-directed mutagenesis we have identified residues that constitute the functional interaction surfaces of delta-dendrotoxin and its voltage-gated potassium channel receptor. delta-Dendrotoxin uses a triangular patch formed by seven side-chains (Lys3, Tyr4, Lys6, Leu7, Pro8,...

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Source

Identifiers

PMID: 10698633
DOI: 10.1006/jmbi.2000.3522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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