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Article

Asymmetric contribution of a selectivity filter gate in triggering inactivation of CaV1.3 channels.

The Journal of general physiology - 5 Feb 2024

Del Rivero Morfin Pedro J, Kochiss Audrey L, Liedl Klaus R, Flucher Bernhard E, Fernández-Quintero Monica L I, Ben-Johny Manu

Abstract excerpt

Voltage-dependent and Ca2+-dependent inactivation (VDI and CDI, respectively) of CaV channels are two biologically consequential feedback mechanisms that fine-tune Ca2+ entry into neurons and cardiomyocytes. Although known to be initiated by distinct molecular events, how these processes obstruct conduction through the channel pore remains poorly defined. Here, focusing on ultrahighly conserved tryptophan...

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Identifiers

PMID: 38175169
DOI: 10.1085/jgp.202313365
PMCID: PMC10771039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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