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Article

PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence

25 Mar 2022

Abstract excerpt

BACKGROUND: Identification of novel molecular target(s) is important for designing newer mechanistically driven approaches for the treatment of prostate cancer (PCa), which is one of the main causes of morbidity and mortality in men. In this study, we determined the role of polo-like kinase 4 (PLK4), which regulates centriole duplication and centrosome amplification (CA), in PCa. MATERIALS AND METHODS: Employing...

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PMID: 35333404
DOI: 10.1002/pros.24342

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PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescencePMID 35333404Read ↗

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