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Article

The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.

Open biology - 1 Feb 2018

Arquint Christian, Cubizolles Fabien, Morand Agathe, Schmidt Alexander, Nigg Erich A

Abstract excerpt

Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated. E3 ubiquitin ligases have been implicated in controlling the levels of several duplication factors, including PLK4, STIL and SAS-6, but the precise mechanisms ensuring centriole homeostasis remain to be fully understood. Here,...

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Source

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Identifiers

PMID: 29445034
DOI: 10.1098/rsob.170253
PMCID: PMC5830536

Genes

STIL
CDK2
PLK4
SKP1

Provenance

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Related research

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The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.PMID 29445034Read ↗

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CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate CancerSemantic proximity Read ↗

Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)Semantic proximity Read ↗

TRIM37: a critical orchestrator of centrosome functionSemantic proximity Read ↗

SCFβ-TRCP promotes cell growth by targeting PR-Set7/Set8 for degradationSemantic proximity Read ↗

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Polo-like kinase 4 autodestructs by generating its Slimb-binding phosphodegron.Semantic proximity Read ↗

SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.Semantic proximity Read ↗

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