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Article

CUL4A ubiquitin ligase: a promising drug target for cancer and other human diseases

1 Feb 2014

Abstract excerpt

The ability of cullin 4A (CUL4A), a scaffold protein, to recruit a repertoire of substrate adaptors allows it to assemble into distinct E3 ligase complexes to mediate turnover of key regulatory proteins. In the past decade, a considerable wealth of information has been generated regarding its biology, regulation, assembly, molecular architecture and novel functions. Importantly, unravelling of its association...

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PMID: 24522884
DOI: 10.1098/rsob.130217

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