Article
New Insights Into the Mechanism of COP9 Signalosome-Cullin-RING Ubiquitin-Ligase Pathway Deregulation in Urological Cancers.
International review of cell and molecular biology - 1 Jan 2016
Gummlich Linda, Kähne Thilo, Naumann Michael, Kilic Ergin, Jung Klaus, Dubiel Wolfgang
Abstract excerpt
Urological cancers are a very common type of cancer worldwide and have alarming high incidence and mortality rates, especially in kidney cancers, illustrate the urgent need for new therapeutic targets. Recent publications point to a deregulated COP9 signalosome (CSN)-cullin-RING ubiquitin-ligase (CRL) pathway which is here considered and investigated as potential target in urological cancers with strong focus on...
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