Article

CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesis

2023-02-18

Abstract excerpt

Centrioles are evolutionarily conserved microtubule-based organelles critical to form centrosomes and cilia, which act as microtubule-organizing, signaling and motility centers. Biogenesis and maintenance of centrioles with proper number, size and architecture are crucial for their functions during development and physiology. Consequently, their deregulation causes developmental disorders and cancer. Although cent...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eacf2e41-6d20-5f8e-9904-45ca028f2202
DOI: 10.1101/2023.02.16.528810

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CCDC15 localizes to the centriole inner scaffold and regulates centriole integrity and ciliogenesisDOI 10.1101/2023.02.16.528810Read

Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffoldSemantic proximity Read

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and AppendagesSemantic proximity Read

Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control.Semantic proximity Read

A ciliopathy complex builds distal appendages to initiate ciliogenesisSemantic proximity Read

The connecting cilium inner scaffold provides a structural foundation to maintain photoreceptor integritySemantic proximity Read

NDE1 Localizes to the Subdistal Appendages to Maintain Centrosome Integrity and Microtubule OrganizationSemantic proximity Read

Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.Semantic proximity Read

CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.Semantic proximity Read

Evolutionary conservation of centriole rotational asymmetry in the human centrosomeSemantic proximity Read

The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation.Semantic proximity Read

Multicilin drives centriole biogenesis via E2f proteins.Semantic proximity Read

Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.Semantic proximity Read