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Investigation of hepatic warfarin metabolism activity in rodenticide-resistant black rats (Rattus rattus) in Tokyo by in situ liver perfusion.

Pesticide biochemistry and physiology - 1 Jun 2018

Takeda Kazuki, Ikenaka Yoshinori, Tanaka Kazuyuki D, Nakayama Shouta M M, Tanikawa Tsutomu, Mizukawa Hazuki, Ishizuka Mayumi

Abstract excerpt

Anti-blood coagulation rodenticides, such as warfarin, have been used all over the world. They inhibit vitamin K epoxide reductase (VKOR), which is necessary for producing several blood clotting factors. This inhibition by rodenticides results in lethal hemorrhage in rodents. However, heavy usage of these agents has led to the appearance of rodenticide-resistant rats. There are two major mechanisms underlying...

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Identifiers

PMID: 29891376
DOI: 10.1016/j.pestbp.2018.03.018

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