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Article

Lung cancer mutation profile of EGFR, ALK, and KRAS: Meta-analysis and comparison of never and ever smokers.

Lung cancer (Amsterdam, Netherlands) - 1 Dec 2016

Chapman Aaron M, Sun Kathie Y, Ruestow Peter, Cowan Dallas M, Madl Amy K

Abstract excerpt

Lung cancer is the leading cause of cancer-related mortality. While the majority of lung cancers are associated with tobacco smoke, approximately 10-15% of U.S. lung cancers occur in never smokers. Evidence suggests that lung cancer in never smokers appears to be a distinct disease caused by driver mutations which are different than the genetic pathways observed with lung cancer in smokers. A meta-analysis of...

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Source

Identifiers

PMID: 27987580
DOI: 10.1016/j.lungcan.2016.10.010

Genes

EGFR
ALK
KRAS
EML4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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