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Article

Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2008

Riely Gregory J, Kris Mark G, Rosenbaum Daniel, Marks Jenifer, Li Allan, Chitale Dhananjay A, Nafa Khedoudja, Riedel Elyn R, Hsu Meier, Pao William, Miller Vincent A, Ladanyi Marc

Abstract excerpt

PURPOSE: KRAS mutations are found in approximately 25% of lung adenocarcinomas in Western countries and, as a group, have been strongly associated with cigarette smoking. These mutations are predictive of poor prognosis in resected disease as well as resistance to treatment with erlotinib or gefitinib. EXPERIMENTAL DESIGN: We determined the frequency and type of KRAS codon 12 and 13 mutations and characterized...

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Identifiers

PMID: 18794081
DOI: 10.1158/1078-0432.CCR-08-0646
PMCID: PMC2754127

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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