Article
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2008
Riely Gregory J, Kris Mark G, Rosenbaum Daniel, Marks Jenifer, Li Allan, Chitale Dhananjay A, Nafa Khedoudja, Riedel Elyn R, Hsu Meier, Pao William, Miller Vincent A, Ladanyi Marc
Abstract excerpt
PURPOSE: KRAS mutations are found in approximately 25% of lung adenocarcinomas in Western countries and, as a group, have been strongly associated with cigarette smoking. These mutations are predictive of poor prognosis in resected disease as well as resistance to treatment with erlotinib or gefi...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Female
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins p21(ras)
- Smoking
- ras Proteins