Article
Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer.
PloS one - 1 Jan 2016
Saber Ali, van der Wekken Anthonie J, Kerner Gerald S M A, van den Berge Maarten, Timens Wim, Schuuring Ed, ter Elst Arja, van den Berg Anke, Hiltermann T Jeroen N, Groen Harry J M
Abstract excerpt
Mutations in epithelial growth factor receptor (EGFR), as well as in the EGFR downstream target KRAS are frequently observed in non-small cell lung cancer (NSCLC). Chronic obstructive pulmonary disease (COPD), an independent risk factor for developing NSCLC, is associated with an increased activation of EGFR. In this study we determined presence of EGFR and KRAS hotspot mutations in 325 consecutive NSCLC patients...
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