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Article

Differential properties of KRAS transversion and transition mutations in non-small cell lung cancer: associations with environmental factors and clinical outcomes.

BMC cancer - 8 Nov 2022

Sato Koichi, Akamatsu Hiroaki, Koh Yasuhiro, Ogawa Koichi, Isa Shun-Ichi, Ando Masahiko, Tamiya Akihiro, Kubo Akihito, Kitagawa Chiyoe, Kawaguchi Tomoya, Yamamoto Nobuyuki

Abstract excerpt

BACKGROUND: KRAS-mutated non-small cell lung cancer (NSCLC) accounts for 23-35% and 13-20% of all NSCLCs in white patients and East Asians, respectively, and is therefore regarded as a major therapeutic target. However, its epidemiology and clinical characteristics have not been fully elucidated because of its wide variety of mutational subtypes. Here, we focused on two distinct base substitution types:...

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Identifiers

PMID: 36348317
DOI: 10.1186/s12885-022-10246-7
PMCID: PMC9641926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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