Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Driver mutations determine survival in smokers and never-smokers with stage IIIB/IV lung adenocarcinomas.

Cancer - 1 Dec 2012

Paik Paul K, Johnson Melissa L, D'Angelo Sandra P, Sima Camelia S, Ang Daphne, Dogan Snjezana, Miller Vincent A, Ladanyi Marc, Kris Mark G, Riely Gregory J

Abstract excerpt

BACKGROUND: The authors previously demonstrated that never-smokers with stage IIIB/IV nonsmall cell lung cancer (NSCLC) lived 50% longer than former/current smokers. This observation persisted after adjusting for age, performance status, and sex. In this study, the authors hypothesized that smoking-dependent differences in the distribution of driver mutations may explain differences in prognosis between these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to ErbB Receptors

Share to Gene Rearrangement

Share to Lung Neoplasms

Share to Mutation

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22605530
DOI: 10.1002/cncr.27637
PMCID: PMC3424296

Genes

KRAS
ALK
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Driver mutations determine survival in smokers and never-smokers with stage IIIB/IV lung adenocarcinomas.PMID 22605530Read ↗

Distinct clinical features and outcomes in never-smokers with nonsmall cell lung cancer who harbor EGFR or KRAS mutations or ALK rearrangement.Semantic proximity Read ↗

EGFR, ALK, RET, KRAS and BRAF alterations in never-smokers with non-small cell lung cancerSemantic proximity Read ↗

Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis.Semantic proximity Read ↗

Lung cancer mutation profile of EGFR, ALK, and KRAS: Meta-analysis and comparison of never and ever smokers.Semantic proximity Read ↗

Real World Characterization of Advanced Non-Small Cell Lung Cancer in Never Smokers by Actionable Mutation Status.Semantic proximity Read ↗

Republished: lung cancer in never-smokers. Does smoking history matter in the era of molecular diagnostics and targeted therapy?Semantic proximity Read ↗

Differences in EGFR and KRAS mutation spectra in lung adenocarcinoma of never and heavy smokersSemantic proximity Read ↗

Proportion and clinical features of never-smokers with non-small cell lung cancer.Semantic proximity Read ↗

Former smokers with non-small-cell lung cancers: a comprehensive investigation of clinicopathologic characteristics, oncogenic drivers, and prognosis.Semantic proximity Read ↗

Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers.Semantic proximity Read ↗

Lung cancer in never-smokers. Does smoking history matter in the era of molecular diagnostics and targeted therapy?Semantic proximity Read ↗

Clinical characteristics of lung cancer in never-smokers: a multicenter Saudi cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.