Article
Driver mutations determine survival in smokers and never-smokers with stage IIIB/IV lung adenocarcinomas.
Cancer - 1 Dec 2012
Paik Paul K, Johnson Melissa L, D'Angelo Sandra P, Sima Camelia S, Ang Daphne, Dogan Snjezana, Miller Vincent A, Ladanyi Marc, Kris Mark G, Riely Gregory J
Abstract excerpt
BACKGROUND: The authors previously demonstrated that never-smokers with stage IIIB/IV nonsmall cell lung cancer (NSCLC) lived 50% longer than former/current smokers. This observation persisted after adjusting for age, performance status, and sex. In this study, the authors hypothesized that smoki...
Topics
- Adenocarcinoma
- Adenocarcinoma of Lung
- Adult
- Aged
- Aged, 80 and over
- Anaplastic Lymphoma Kinase
- ErbB Receptors
- Female
- Gene Rearrangement
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasm Staging