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Article

Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging.

Aging - 31 May 2017

Petrini Stefania, Borghi Rossella, D'Oria Valentina, Restaldi Fabrizia, Moreno Sandra, Novelli Antonio, Bertini Enrico, Compagnucci Claudia

Abstract excerpt

Nuclear integrity and mechanical stability of the nuclear envelope (NE) are conferred by the nuclear lamina, a meshwork of intermediate filaments composed of A- and B-type lamins, supporting the inner nuclear membrane and playing a pivotal role in chromatin organization and epigenetic regulation. During cell senescence, nuclear alterations also involving NE architecture are widely described. In the present study,...

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Identifiers

PMID: 28562315
DOI: 10.18632/aging.101248
PMCID: PMC5472744

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SIRT7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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