Article
IVNS1ABP mutation drives cellular senescence in newly identified progeroid neuropathy.
Nature communications - 19 Mar 2026
Yuan Fang, Tan Ye Sing, Wang Haofei, Ali Ain Nur, Yuan Qiang, Chou Shu-Min, Yen Yu-Hsin, Narayanan Gunaseelan, Zhou Lei, Shboul Mohammad, Bonnard Carine, Reversade Bruno, Zhang Su-Chun
Abstract excerpt
We identified a new progeroid syndrome with severe neuropathy and intellectual deficits but its underlying cellular and molecular mechanism is unknown. Exome sequencing revealed a homozygous mutation in the IVNS1ABP gene, which encodes IVNS1ABP, an influenza virus non-structural protein-1 binding protein. To investigate disease mechanisms, we generated isogenic induced pluripotent stem cells (iPSCs) from patient...
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