Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sp1 Is Essential for p16INK4a Expression in Human Diploid Fibroblasts during Senescence

17 Jan 2007

Abstract excerpt

BACKGROUND: p16(INK4a) tumor suppressor protein has been widely proposed to mediate entrance of the cells into the senescent stage. Promoter of p16(INK4a) gene contains at least five putative GC boxes, named GC-I to V, respectively. Our previous data showed that a potential Sp1 binding site, within the promoter region from -466 to -451, acts as a positive transcription regulatory element. These results led us to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17225865
DOI: 10.1371/journal.pone.0000164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sp1 Is Essential for p16INK4a Expression in Human Diploid Fibroblasts during SenescencePMID 17225865Read ↗

The transcription factor <scp>S</scp>p1 is responsible for aging‐dependent altered nucleocytoplasmic traffickingSemantic proximity Read ↗

The Cyclin-dependent Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA DamageSemantic proximity Read ↗

Regulation of Cellular Senescence and p16 Expression by Id1 and E47 Proteins in Human Diploid FibroblastSemantic proximity Read ↗

Regulation of p53 during senescence in normal human keratinocytesSemantic proximity Read ↗

Differential Roles for Cyclin-Dependent Kinase Inhibitors p21 and p16 in the Mechanisms of Senescence and Differentiation in Human FibroblastsSemantic proximity Read ↗

Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Semantic proximity Read ↗

Role of the p16 tumor suppressor gene in cancer.Semantic proximity Read ↗

The lncRNA MIR31HG regulates p16(INK4A) expression to modulate senescence.Semantic proximity Read ↗

Quantitative assessment of higher‐order chromatin structure of the INK4/ARF locus in human senescent cellsSemantic proximity Read ↗

p16 INK4A is a robust in vivo biomarker of cellular aging in human skinSemantic proximity Read ↗

Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A).Semantic proximity Read ↗

p16INK4a in cellular senescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.