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Article

Persistence versus reversion of 3TC resistance in HIV-1 determine the rate of emergence of NVP resistance.

Viruses - 1 Aug 2012

Rath Barbara A, Olshen Richard A, Halpern Jerry, Merigan Thomas C

Abstract excerpt

When HIV-1 is exposed to lamivudine (3TC) at inhibitory concentrations, resistant variants carrying the reverse transcriptase (RT) substitution M184V emerge rapidly. This substitution confers high-level 3TC resistance and increased RT fidelity. We established a novel in vitro system to study the effect of starting nevirapine (NVP) in 3TC-resistant/NNRTI-naïve clinical isolates, and the impact of maintaining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23012621
DOI: 10.3390/v4081212
PMCID: PMC3446758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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