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Article

Might the M184V substitution in HIV-1 RT confer clinical benefit?

AIDS reviews - 1 Jan 2000

Petrella Marco, Wainberg Mark A

Abstract excerpt

The M184V substitution in HIV-1 RT develops rapidly following initiation of therapy with 3TC and confers high-level phenotypic resistance to this drug both in vitro and in vivo. Interestingly, the presence of M184V is also associated with alteration of several mechanisms relating to RT function that include decreased RT processivity, reduced nucleotide-dependent primer unblocking, increased fidelity,...

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PMID: 12555696

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Might the M184V substitution in HIV-1 RT confer clinical benefit?PMID 12555696Read ↗

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The M184V substitution in human immunodeficiency virus type 1 reverse transcriptase delays the development of resistance to amprenavir and efavirenz in subtype B and C clinical isolates.Semantic proximity Read ↗

The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses.Semantic proximity Read ↗

The influence of 3TC resistance mutation M184I on the fidelity and error specificity of human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

Treatment Management Challenges in Naïve and Experienced HIV-1-Infected Individuals Carrying the M184V MutationSemantic proximity Read ↗

The M184V mutation: what it does, how to prevent it, and what to do with it when it's there.Semantic proximity Read ↗

Differential maintenance of the M184V substitution in the reverse transcriptase of human immunodeficiency virus type 1 by various nucleoside antiretroviral agents in tissue culture.Semantic proximity Read ↗

Treatment Management Challenges in Naïve and Experienced HIV-1-Infected Individuals Carrying the M184V Mutation.Semantic proximity Read ↗

New resistance mutations to nucleoside reverse transcriptase inhibitors at codon 184 of HIV-1 reverse transcriptase (M184L and M184T).Semantic proximity Read ↗

The impact of the M184V resistance mutation on treatment outcomes in patients with HIV infection: a systematic review and meta-analysis.Semantic proximity Read ↗

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