Article
Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.
Antimicrobial agents and chemotherapy - 1 Jul 2002
Diallo Karidia, Oliveira Maureen, Moisi Daniela, Brenner Bluma, Wainberg Mark A, Götte Matthias
Abstract excerpt
We cultured lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) variants over an extended period of time in the presence of zidovudine and observed a premature reversion of the resistance-conferring M184V mutation. These data suggest that the presence of ZDV amplifies differences in replication capacity between wild-type HIV-1 and the mutant variant.
Topics
- Anti-HIV Agents
- Drug Resistance, Viral
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Lamivudine
- Mutation
- Virus Replication
- Zidovudine