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Article

Differential persistence of transmitted HIV-1 drug resistance mutation classes.

The Journal of infectious diseases - 15 Apr 2011

Jain Vivek, Sucupira Maria C, Bacchetti Peter, Hartogensis Wendy, Diaz Ricardo S, Kallas Esper G, Janini Luiz M, Liegler Teri, Pilcher Christopher D, Grant Robert M, Cortes Rodrigo, Deeks Steven G, Hecht Frederick M

Abstract excerpt

BACKGROUND: Transmitted human immunodeficiency virus type 1 (HIV-1) drug resistance (TDR) mutations can become replaced over time by emerging wild-type viral variants with improved fitness. The impact of class-specific mutations on this rate of mutation replacement is uncertain. METHODS: We studied participants with acute and/or early HIV infection and TDR in 2 cohorts (San Francisco, California, and São Paulo,...

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Identifiers

PMID: 21451005
DOI: 10.1093/infdis/jiq167
PMCID: PMC3107558

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