Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of Lamivudine Resistance in Human Immunodeficiency Virus Type 1-Infected Individuals: the Relative Roles of Drift and Selection

15 Jul 2000

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) rapidly develops resistance to lamivudine during monotherapy, typically resulting in the appearance at position 184 in reverse transcriptase (RT) of isoleucine instead of the wild-type methionine (M184I) early in therapy, which is later replaced by valine (M184V). M184V reduces viral susceptibility to drug in vitro by approximately 100-fold, but also results in a lower...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10864635
DOI: 10.1128/jvi.74.14.6262-6268.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of Lamivudine Resistance in Human Immunodeficiency Virus Type 1-Infected Individuals: the Relative Roles of Drift and SelectionPMID 10864635Read ↗

In Vivo Fitness Cost of the M184V Mutation in Multidrug-Resistant Human Immunodeficiency Virus Type 1 in the Absence of LamivudineSemantic proximity Read ↗

The impact of the M184V substitution in HIV-1 reverse transcriptase on treatment response.Semantic proximity Read ↗

The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus.Semantic proximity Read ↗

The M184V mutation in HIV-1 reverse transcriptase reduces the restoration of wild-type replication by attenuated viruses.Semantic proximity Read ↗

HIV fitness and resistance as covariates associated with the appearance of mutations under antiretroviral treatment.Semantic proximity Read ↗

Initial appearance of the 184Ile variant in lamivudine-treated patients is caused by the mutational bias of human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

The impact of the M184V substitution on drug resistance and viral fitness.Semantic proximity Read ↗

Increased polymerase fidelity of lamivudine-resistant HIV-1 variants does not limit their evolutionary potential.Semantic proximity Read ↗

Pressure of zidovudine accelerates the reversion of lamivudine resistance-conferring M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1.Semantic proximity Read ↗

Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase.Semantic proximity Read ↗

Lamivudine-resistant human immunodeficiency virus type 1 variants (184V) require multiple amino acid changes to become co-resistant to zidovudine in vivo.Semantic proximity Read ↗

Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.